Saturday, 30 January 2016

Approach to pain in the arm and hand

Pain in the arm and hand: diagnostic strategy model

Probabiligy diagnosis

  • Dysfunction of the cervical spine 
  • Disorders of the shoulder
  • Medial or lateral epicondylitis
  • Overuse tendonitis of the wrist
  • Carpal tunnel syndrome 
  • Osteoarthritis of the thumb and DIP joints
Serious disorders not to be missed
  • Cardiovascular 
    • angina
    • myocardial infarction 
    • axillary vein thrombosis
  • Neoplasia
    • pancoast tumour
    • bone tumours
  • Severe infections
    • septic arthritis (shoulder/elbow)
    • osteomyelitis
    • infections of tendon sheath and fascial spaces of hand 
Pitfalls (often missed)
  • Entrapment neuropathies
  • Pulled elbow 
  • Foreign body 
  • Rarities
    • polymyalgia rheumatica
    • Reflex sympathetic dystrophy
    • Thoracic outlet syndrom e
    • Arm claudication 
    • kienbock disorder

Approach to neck pain

Neck pain: diagnostic strategy model

Probability diagnosis 


  • vertebral dysfunction 
  • traumatic strain or sprain 
  • cervical spondylosis

Serious disorders not to be missed

  • Cardiovascular
    • angina
    • subarachnoid haemorrhage
    • arterial dissection 
  • Neoplasia
    • primary 
    • metastasis --> breast, prostate and lung. also kidney, thyroid and melanoma.
    • Pancoast tumour --> Horner's syndrome
  • Severe infections
    • osteomyelitis
    • meningitis
  • Vertebral fractures or dislocation

Pitfalls

  • Disc prolapse
  • Myelopathy
  • Cervical lymphadenitis
  • Fibromyalgia syndrome 
  • Outlet compression syndrome 
  • Polymyalgia rheumatica
  • Ankylosing spondylitis
  • Rheumatoid arthritis
  • Oesophageal foreign bodies and tumours
  • Paget disease

Red Flags

  • History of major trauma
  • Age > 50 years
  • Constant pain (day and night)
  • Fever > 38 
  • Anterior neck pain 
  • History of cancer
  • Unexplained weight loss
  • Neurological deficit
  • Radicular pain in arm 
  • Rheumatoid arthritis
  • Down syndrome 






Thursday, 28 January 2016

Trachoma

Condition

  • Trachoma 
Definition
  • repeat infection by bacteria Chlamydia Trachomatis resulting in in turning of the eyelid, the eyelashes can cause irritation and thickening of the cornea and resulting in blindness.
Main features
  • Common in indigenous people 
  • Scratchy eyes and watery discharge +/- red eye
Management
  • if over 6 kg and not pregnant: azithromycin as single dose
  • if under 6 kg or pregnant: erythromycin or roxithromycin for 21 days 
  • or oily tetracycline eyedrops 1 bd for 3-6 weeks
  • Check and treat household contacts
  • check routinely for follicles of trachoma
Reference

John Murtagh's general practice 5th edition 

Wednesday, 27 January 2016

Ear infection (Indigenous)

Ear infections

** Acute otitis media should be treated early and aggressively with antibiotics to prevent chronic suppurative otitis media, which is very difficult to cure once established.**

Treatment guidelines as per the CARPA standard treatment manual:

Chronic suppurative otitis media (CSOM)

  • Large perforation with pus (discharge) for more than 2 weeks
  • or small perforation and pus (discharge) for 6 weeks or more 
    • if pus (discharge)started in last 6 weeks - treat as AOMwiP
  • Clean with tissue spears or syringe with povidone iodine diluted 1:20
  • Give ciprofloxacin ear drops 5 drops 2-4 times a day
  • Teach parents to clean /dry mop ears with tissue spears, put in drops
  • Talk with parents about stimulating speech and language in young child - lots of talking, going to preschool, child care, early learning program 
  • Review weekly 
  • Continue ciprofloxacin until CSOM resolved - no pus for more than 3 days
  • If still discharge after 3 months -- persistent CSOM
    • Refer to ENT 
    • Hearing test 
    • May need IV antibiotic 

Approach the painful ear

Murtagh's Diagnostic strategy model

** one of every 25 patients in general practice will present with an earache**

** Pneumatic otoscopy greatly assists diagnosis since the most valuable sign of otitis media is absent or diminished motility of the TM**

Probability diagnosis

  • Otitis media (viral or bacterial) **Indigenous health**
  • Otitis externa 
  • TMJ arthralgia 
  • Eustachian tube dysfunction 


Serious disorders not to be missed

  • Neoplasia of external ear
  • Cancer of other sites e.g. tongue, throat
  • Herpes zoster (Ramsay-Hunt syndrome)
  • Acute mastoiditis
  • Cholesteatoma
  • Necrotising otitis externa


Pitfalls (often missed)

  • Foreign bodies in ear
  • Hard ear wax
  • Barotrauma 
  • Dental causes
  • Referred pain: neck, throat
  • Unerupted wisdom tooth and the dental causes
  • Facial neuralgias esp. glossopharyngeal
  • Post tonsillectomy:
    • - from the wound 
    • - from TMJ due to mouth gag

Red flags


  • Offensive discharge > 9 days
  • Downward displacement of pinna 
  • Swelling behind ear
  • Neurological symptoms (e.g. headaches, drowsiness)
  • Older person: unexplained, intractable ear pain 
  • Persistent fever 


Acute otitis externa

Condition
  • Acute otitis externa
Definition 
  • infection of the ear canal
  • Common responsible organisms
    • Bacteria
      • Pseudomonas sp. 
      • Escherichia coli
      • S. aureus
      • Proteus sp. 
      • Klebsiella sp. 
    • Fungi
      • Candida albicans
      • Aspergillus sp. 
Clinical features 
  • Itching at first
  • Pain (mild to intense)
  • Fullness in ear canal
  • Scant discharge
  • Hearing loss
Signs
  • Oedema 
  • Tenderness on moving auricle or jaw
  • Erythema 
  • Discharge (offensive if coliform)
  • Pale cream 'wet blotting paper' debris - C. albicans
  • Black spores of aspergillum nigra 
  • TM granular or dull red 
Management
  • Keep ear canal as dry as possible 
  • Remove discharge from the ear canal by aural toilet 6 hourly
  • use sofradex or kenacomb 2-3 drops tads 
  • pump the triages ( by pressing on it repeatedly without causing pain) for 30 seconds after instilling ear drops 
  • Systemic antibiotic offers no benefits unless there are systemic symptoms
  • Keep the ear dry during, and for 2 weeks after, treatment
Reference
  • eTG
  • John Murtagh's general practice 5th edition 

Cholesteatoma

Condition
  • cholesteatoma
Definition 
  • a sac of keratinising squamous epithelium that arises from a perforation involving the periphery of the TM 
  • it is dangerous to the ear because it tends to expand and destroy adjacent structures, including the TM, ossicular chain and cochlear
Diagnosis 
  • By recognising " the unsafe ear " / attic perforation on the tympanic membrane 
Treatment
  • surgical removal is necessary
Reference
  • John Murtagh's General practice 5th edition 

Chronic suppurative otitis media

Condition

  • Chronic suppurative otitis media 
Definition 
  • is an infection of the middle ear with a perforated eardrum and discharge for at least 6 weeks 
Treatment
  • Ciprofloxacin 0.3% ear drops 5 drops instilled into the affected ear, 12 hourly until the middle ear has been free of discharge for at least 3 days
  • If a recent perforation (i.e. within the last 6 weeks) caused ear discharge, treat with both oral antibiotic therapy and topical antibiotic therapy. Inadequate evidence for topical corticosteroids
Reference 
  • eTG

Acute Otitis Media

Condition

  • Acute Otitis Media 
Definition 
  • Middle ear infection 
  • The common organisms are viral (25%), streptococcus pneumonia, Haemophilus influenza and Moraxella catarrhalis 
Main features
  • Fever, irritability, otalgia and otorrhoea 
  • TM: translucency, colour, position and motility
  • self-limiting (60% of children treated with placebo became pain-free in 24 hours, and spontaneous resolution AOM occurs in approximately 80% of children)
  • According to eTG, diagnosis is likely if there is 
    • acute onset of signs and symptoms 
    • and a demonstrable middle ear effusion (MEE) characterised by any of the following:
      • Bulging of the tympanic membrane
      • Limited or absent movement of the tympanic membrane in response to changes in air pressure from a pneumatic otoscope
      • An air-fluid level behind the tympanic membrane
      • Perforation of the tympanic membrane with otorrhoea 
    • Signs and symptoms of middle ear inflammation, characterised by redness of the tympanic membrane
    • The incidence of mastoiditis in children with untreated AOM is 1: 1000
Management
  • Avoid the routine use of antibiotic therapy for acute otitis media
  • Initial antibiotic for all children with systemic features and may be required in children younger than 6 months without systemic features. The treatment recommendations apply regardless whether the tympanic membrane has perforated
  • Children without systemic features
    • In children aged 6 months or older --> observe, if symptoms persist more than 48 hrs, consider antibiotic treatment
    • In children aged younger than 6 months --> treat with antibiotic
  • Children with systemic features
    • amoxycillin 15 mg/kg up to 500 mg orally, 8 hourly for 5 days
    • or (for patients suspected to be non adherent) amoxycillin 30 mg/kg to 1 g orally, 12 hourly for 5 days
    • Patients who have an inadequate response to amoxycillin therapy within 48 to 72 hours may have infection caused by a beta-lactamase- producing strain of H. influenza or M. catarrhalis, adding clavulanate provides increased cavity against these pathogens. Use
      • Amoxycillin + clavulanate 22.5 + 3.2 mg/kg up to 500 + 125 mg orally, 8 hourly for 5 to 7 days
    • For patients hypersensitive to penicillins use 
      • cefuroxime (child 3 months to 2 years: 10mg/kg up to 125mg; 2 years or older: 15mg/kg up to 500 mg) orally, 12 hourly for 5 days
      • trimethoprim + sulfamethoxazole (child 1 month or older) 4 + 20 mg/kg up to 160 + 800 mg orally, 12 hourly for 5 days 
References
  • eTG

Tuesday, 26 January 2016

Intersitial lung diseases

Condition

  • Interstitial lung disease 
Definition
  • Interstitial lung diseases comprise a group of disorders that have the common features of inflammation and fibrosis of the inter alveolar septum, representing a non-specific reaction of the lung to injury of various causes
Main features
  • Dyspnoea and dry cough
  • fine inspiratory crackles at lung base
  • finger clubbing 
  • PFTs
    • restrictive ventilatory deficit
    • decrease in gas transfer factor
  • Characteristic x-ray changes
Causes
  • sarcoidosis
  • cryptogenic fibrosing alveolitis
  • extrinsic allergic alveolitis
  • drug induced
  • lymphangitis carcinomatosis
  • acute pulmonary oedema
  • immunological 
Treatment
  • Depends on cause

Sarcoidosis

Condition

  • Sarcoidosis
Definitions
  • Sarcoidosis is a multisystemic disorder of unknown aetiology which is characterised by non-caseating granulomatous inflammation that involves the lung in about 90% of affected patients. A characteristic feature is bilateral hillier lymphadenopathy, which is often symptomless and detected on routine chest x-ray (CXR). Radiological lung involvement can be associated with or occur independently of hillier lymphadenopathy. 
Main features
  • May be asymptomatic (one-third)
  • Onset usually third or fourth decade
  • Bilateral hilar lymphadenopathy (on CXR)
  • Cough
  • Fever, malaise, arthralgia
  • Erythema nudism
  • Ocular lesions (e.g. anterior uveitis)
  • Other multiple organ lesions (uncommon)
  • Overall mortality 2-5%
Investigation
  • diagnosis is usually made by biopsy
  • Female with erythema nodosum with an acute swinging fever, malaise and arthralgia in a young adult female is diagnostic of sarcoidosis
Treatment
  • Referral
Reference
  • John Murtagh's general practice 5th edition 

Approach to Dyspnoea

Murtagh's diagnostic model 

Probability diagnosis 

Serious disorders not to be missed

  • cardiovascular:
    • acute heart failure (e.g. AMI)
    • Arrhythmia 
    • Pulmonary embolism 
    • Pulmonary hypertension 
    • Dissecting aneurysm 
    • Cardiomyopathy
    • Pericardial tamponade
    • Anaphylaxis
  • Neoplasia
    • Bronchial carcinoma
  • Severe infections
    • SARS
    • avian influenza
    • penumonia 
    • acute epiglottis (children)
  • Respiratory disorders
    • inhaled foreign body 
    • upper airways obstruction 
    • pneumothorax
    • atelectasis 
    • pleural effusion 
    • tuberculosis 
  • Acute respiratory distress syndrome
    • infective polyneuritis
    • poliomeylitis 

Pitfalls 

  • Interstital lung disorder:
    • fibrosing alveolitis
    • extrinsic allergic alveolitis
    • Sarcoidosis
  • Chemical pneumonitis
  • Metabolic acidosis 
  • Radiotherapy 
  • Kidney failure 
  • Multiple smal pulmonary emboli 

Monday, 25 January 2016

Heart Failure

Condition

  • Heart failure 
Definitions
  • Occurs when the heart is unable to maintain sufficient cardiac output to meet the demands of the body 
Main features
  • increasing dyspnoea progressing to (in order):
    • fatigue, especially exertion fatigue
    • paroxysmal nocturnal dyspnoea 
    • weight change : gain or loss 
    • Dizzy spells/syncope
    • Palpitations 
    • Ankle oedema
  • Signs
    • left heart failure
      • tachycardia
      • low volume pulse
      • tachypnoea
      • laterally displaced apex heart 
      • bilateral basal crackles
      • Gallop rhythm 
      • Pleural effusion 
      • Poor peripheral perfusion 
    • Right heart failure 
      • elevated jugular venous pressur e
      • right ventricular heave
      • peripheral/ankle oedema 
      • hepatomegaly 
      • ascites
  • Causes of heart failure
    • Systolic heart failure 
      • The most common cause: myocardial infarction 
      • valvular heart disease, mainly aortic and mitral incompetence
      • high output states (e.g. anaemia. hyperthyroidism, paget disease)
      • Non-ischaemic idiopathic dilated cardiomyopathy
      • Viral cardiomyopathy 
      • ETOH cardiomyopathy
      • Other cardiomyopathies - diabetic, familial
      • persistent arrhythmias, especially atrial fibrillation 
      • other systemic illness (e.g. sarcoidosis, scleroderma, myxoedema)
    • Diastolic heart failure
      • ischaemic heart disease
      • systemic hypertension 
      • aortic stenosis 
      • atrial fibrillation 
      • hypertrophic cardiomyopathy 
      • idiopathic 
      • pericardial disease
Investigation 
  • Office test: ECG 
  • Blood test: FBE, UEC, TFT, LFT, B type natriuretic Peptide (in uncertain cases)
  • Imaging
    • Chest x-ray 
    • Echocardiography
Management
  • Prevention is the key. Approximately 50% of patients with heart failure die within 5 years of diagnosis
  • Treat or remove precipitating factors
  • General non-pharmacological management
    • education and support
    • smoking: encourage no smoking 
    • refer for a rehabilitation program with interdisciplinary care
    • Encourage physical activity especially when symptoms absent or mild 
    • Rest if symptoms are severe 
    • Weight reduction if obese
    • salt restriction: advice < 2g salt per day  
    • Water restriction 
    • Limit caffeine to 1-2 cups coffee/tea a day
    • Limit alcohol to 1 SD a day 
    • Fluid aspiration if pleural effusion or pericardial effusion if present 
    • Daily weighing - check significant weight gain or loss
    • Other general measures: optimise cardiovascular risk factors, monitor emotional factors including depression, regular review, vaccination (annual influenza, 5 yearly pneumococcus), 2 yearly echocardiography
  • Drug therapy
    • Please refer to Heart Failure Medication Titration Plan from Queensland Government. It provides excellent guidance on how to titrate ACE inhibitor, beta blocker and mineralocorticoid receptor antagonist. link
    • Digoxin can also be used in controlling rapid AF 
    • Device-based heart failure treatments : implantable cardiac defibrillators, biventricular pacemakers and left ventricular assist devices 
Reference
- John Murtagh's General Practice 5th edition 
- RACGP Check Program: Heart failure 

Pulmonary effusion

Condition

  • Pulmonary effusion 
Main features
  • Normal pleural space has 10-20 ml fluid
  • Can be detected on x-ray if > 300 ml fluid in pleural space
  • Can be detected clinically if > 500 ml fluid 
  • Can be sub pulmonary - simulates a raised diaphragm 
  • May be asymptomatic 
  • Dyspnoea common with large effusion 
  • Chest pain in setting of pleuritis, infection or trauma 
  • Signs: mid line trachea, reduce in chest wall movement, stony dull percussion note, reduce in breath sounds, absent or decreased vocal fremitus and no adventitious sounds 
  • The fluid may be transudate or exudate (diagnosed by aspirate)
  • If blood stained - malignancy, pulmonary infarction , TB
The effusion fluid can be classified into transudate and exudate 

  • Transudate (protein content < 30g/L, lactic dehydrogenase < 200 IU/L)
    • Causes 
      • Heart failure (90% of cases)
      • Hypoproteinaemia e.g. nephrotic syndrome
      • Liver failure with ascites
      • Constrictive pericarditis
      • Hypothyroidism 
      • Ovarian tumour - right sided effusion (Meigs syndrome)
  • Exudate
    • Protein content > 30 g/L; lactic dehydrogenase > 200 IU/L
    • Causes
      • Infection - bacterial pneumonia, pleurisy, empyema, TB, viral 
      • Malignancy - bronchial carcinoma, mesothelioma, metastatic 
      • Pulmonary infarction 
      • Connective tissue diseases (e.g. SLE, RA)
      • Acute pancreatitis 
      • Lymphoma 
      • Sarcoidosis 
      • HIV with parasitic pneumonia
Management
  • Depends on the extend of the effusion 
  • Aspiratin may be required to ascertain diagnosis 
Reference:
John Murtagh's General Practice 5th edition 

Approach to dysphagia

Approach to dysphagia 


Murtagh's diagnostic models 

** Excluding oropharyngeal infections and strokes**
** Although dysphagia is a common psychogenic symptom, it must always be taken seriously and investigated.**

Probability diagnosis 


  • Functional 
  • Tablet-induced irritation 
  • Pharynotonsillitis
  • Reflux oesophagitis

Serious disorders not to be missed 

  • Neoplasia
  • AIDS (opportunistic oesophageal infection)
  • Stricture, usually benign peptic stricture
  • Scleroderma
  • Neurological causes:
    • pseudobulbar palsy
    • multiple sclerosis 
    • motor neurone disease (amyotrophic sclerosis) 
    • Parkinson disease

Pitfalls (often missed)

  • Foreign body 
  • Drugs
  • Subacute thyroiditis
  • Extrinsic lesion (lymph nodes, goitre)
  • Upper oesophageal web (e.g. Plummer-Vinson syndrome)
  • Eosinophlic oesophagitis
  • Radiotherapy
  • Achalasia
  • Upper oesophageal spasm 
  • Globus sensation 
  • Rarities 
    • sjogren syndrome
    • aortic aneurysm
    • aberrant right subclavian artery
    • lead poisoning 
    • cervical osteoarthritis (large osteophytes)
    • other neurological causes
    • other mechanical causes
Red Flag Pointers 
  • Age > 50 
  • Recent or sudden onset
  • unexplained weight loss
  • Painful swalloing 
  • Progressive dysphagia 
  • Dysphagia for solids 
  • Hiccoughs
  • Hoarseness
  • Neurological symptom/signs 


Scleroderma (Systemic sclerosis)

Condition

  • Scleroderma 
Definition
  • Chronic systemic autoimmune disease characterised by hardening of the skin 
  • 3 clinical variants
    • limited cutaneous disease, for example, morphea
    • cutaneous with limited organ involvement (CREST: calcinosis, raynaud phenomenon, oesophageal dysmotility, sclerodactyly, telangiectasia + anticentromere antibody)
    • diffuse systemic disease (systemic sclerosis)
Main features
  • Female to male ratio 3:1
  • A progressive disease of multiple organs
  • Raynaud phenomenon 
  • Stiffness of fingers and other skin areas
  • Bird like faces (mouth puckered)
  • Dysphagia and diarrhoea 
  • Respiratory symptoms 
  • Cardiac symptoms such as pericarditis
  • Look for tight skin on chest (Roman breastplate)
Murtagh diagnostic triad
  • Finger discomfort + arthralgia + GORD +/- skin tightness = scleroderma
Investigations
  • ESR may be raised
  • Normocytic normochromic anaemia may be present t
  • ANA test up to 90% positive
  • Rheumatoid factor +ve in 30%
  • Anticentromere antibodies - specific (positive in 90% with limited disease and 5% with diffuse)
  • Antitopoisomerase (anti-Scl-70) antibody is specific but positive in 20% - 40% 
  • Skin biopsy - increase in derma collagen 
Treatment
  • Analgesics for pain 
  • Avoid vasospasm (no smoking, beta blockers, ergotamine); calcium channel blockers such as nifedipine may help Raynaud
  • Treat malabsorption if present, skin emollients
  • D-penicillamine can help if there is significant systemic or cutaneous involvement 
References
1. John Murtagh's general practice 5th edition

Achalasia

Condition

  • Achalasia 
Definition 
  • failure for smooth muscle to relax, which can cause a sphincter to remain closed and fail to open when needed.
Main features
  • Gradual onset of dysphagia for both liquids and solids 
  • Fluctuating symptoms 

Investigations
  • Diagnosis confirmed by barium swallow or manometry 
Treatment 
  • Attacks are often triggered by GORD, so treatment for GORD is sometimes helpful
  • Ingestion of warm water at the commencement of an attack can be helpful
  • GTN spray may shorten an attack 
  • If attacks are frequent and disabling, try:
    • Diltiazem controlled release 180 mg orally, once daily, increasing 240 to 360 mg orally, once daily depending on response and adverse effects
    • isosorbide dinitrate 10 to 20 mg orally, 3-4 times daily 
    • Nifedipine controlled release 20 to 30 mg orally, once daily, increasing to 60 mg orally, once daily depending on response and adverse effects
  • Refractory symptoms may require : injecting botulinum toxin type A into the lower oesophageal sphincter or myotomy of the lower oesophagus
References:
  • John Murtagh's general practice 5th edition 
  • eTG 

Oesophageal cancer

Condition 
  • Oesophageal cancer
Definition
  • Metaplasia of the squamous carcinoma to columnar epithelium 

Main features
  • Dysphagia at beginning of meal 
  • Dysphagia for solid food steadily progressive over weeks
  • Can remain silent and tends to be invasive when diagnosed
  • Hiccoughs may be an early sign
  • Hoarseness and cough (upper third) 
  • Discomfort or pain-throat, retrostenral, inter scapular
  • Weight loss can be striking 
  • Associations: GORD, tobaccco, Barrett oesophagus --> weak evidence that PPIs help to prevent development of malignancy
Investigations
  • Endoscopy
  • SCC (most common) and adenocarcinoma
  • Adenocarcinoma associated with Barrett oesophagus (0.5% per cent per year, life time risk of less than 5%)

Treatment
  • Depends on staging, most likely palliative surgery. 
References
  • John Murtagh's General Practice 5th edition 

Functional dyspepsia

Condition
  • Functional dyspepia 
Definitions
  • Dyspepsia with normal investigations 
Main features
  • heart burn 
  • postprandial fullness
  • early satiety 
  • epigastric pain or burning 
Investigations

  • Serology: FBE, UEC, LFT, Lipase and H. Pylori serology.
  • Endoscopy if indicated 
Management plan
  • lifestyle management 
  • PPI 
References
  • John murtagh's general practice 5th edition 
  • eTG 

Stomach cancer

Condition

  • Stomach cancer
Definitions
  • Cancer develops from the lining of the stomach 
Main features
  • Male to female ratio of 3:1 
  • Usually asymptomatic early 
  • Recent onset dyspepsia in middle age
  • Dyspepsia unresponsive to treatment 
  • Vague fullness or epigastric distension 
  • Dysphagia
  • Onset of anaemia 
  • Risk factors
    • Increasing age
    • blood group A
    • smokers
    • Atrophic gastritis
  • Examination findings
    • conjunctival pallor 
    • enlarged supraclavicular lymph node 
    • epigastric mass
    • Hepatomegaly - hard and irregular edge
Diagnostic triad
  • Malaise + anorexia + dyspepsia + weight loss = stomach cancer
  • Triple loss of appetite + weight + colour = stomach cancer
Treatment
  • surgical excision 

Peptic ulcer

Condition

  • Peptic ulcer 
Definitions
  • a break in the lining of the stomach typically in the stomach or duodenum 
Main features
  • Epigastric pain or discomfort 
  • nausea
  • vomiting 
  • heartburn 
  • nocturnal waking with epigastric pain 
  • An ulcer diagnosis is more likely if there is a family history of ulcer disease or if the patient its making aspirin or another NSAID, and even more so if there is a documented past history of an ulcer

Investigations
  • Office base: none 
  • Pathology test: FBE, UEC, LFT, Lipase to look for anaemia and exclude other pathologies such as pancreatitis or hepatitis 
  • Imaging: probably not useful but one of the surgeons I know always order one before endoscopy 
  • Endoscopy provides the definite diagnosis. Biopsy can help to determine whether H. Pylori is present or not. Antibiotics within the last 4 weeks, or proton pump inhibitor therapy within the past 2 weeks, reduce the accuracy of these biopsies. 

Management 
  • In uncomplicated duodenal ulcer, If H.Pylori is present, eradication. First line therapy is triple therapy. 
    • Omeprazole 20 mg orally twice daily for 7 days 
    • Amoxycillin 1g orally twice daily for 7 days
    • Clarithromycin 500 mg twice daily for 7 days 
  • If patient is hypersensitive to penicillin, metronidazole may be substitued for amoxycillin
    • Omeprazole 20 mg orally twice daily for 7 days
    • Metronidazole 400 mg orally twice daily for 7 days
    • Clarithromycin 500 mg orally twice daily for 7 days 
  • Post treatment test
    • C13 or C14 urea breath test is preferred
    • No antibiotics or bismuth 1 month before the test
    • PPI should be suspended for at least 1 week 
  • Follow up endoscopy is usually not required, exceptions are for gastric ulcer and complicated duodenal ulcers)
  • For more complicated ulcers, large gastric ulcers, ulcers occurring in high risk patients or ulcers associated with NSAID use, ongoing antisecretory therapy with a PPI for about 8 weeks is appropriate.
References:
  • John Murtagh 5th edition genenral practice 
  • eTG

Gastro-oesophageal reflux disease

Condition: GORD

Definition:

  • Extremely common 

Main features:

  • Nausea
  • Bloating and belching 
  • Heartburn 
  • Acid regurgitation, especially lying down at night 
  • Water brash
  • Nocturnal cough with possible asthma like symptoms 
  • Diagnosis usually made on history 
  • investigation usually not needed unless red flag features present
Red flag features


  • Anaemia 
  • Dysphagia 
  • Odynophagia (painful swallowing)
  • Haematemesis or melaena 
  • Unexplained weight loss > 10%
  • Vomiting 
  • Older age > 50 years 
  • Chronic NSAID use
  • Severe symptoms
  • Family history of upper GIT or colorectal cancer
  • short history of symptoms 
Investigations
  • Gastroscopy (around 2/3 patients have normal gastroscopy)

Murtagh's diagnostic triad

Management plan:


  • If mild intermittent symptom (no more than once per week), trial of lifestyle management first:
    • weight reduction 
    • eating smaller meals 
    • drinking most fluid between meals rather than with them
    • avoiding lying down after eating 
    • avoid eating or drinking 2 to 3 hours before bedtime or vigorous exercise
    • elevating the bedhead
    • losing weight 
    • Stopping smoking 
    • Decreasing alcohol consumption 
  • Pharmacological intervention 
    • MgOH + Aluminium hydroxider preparations 10 to 20 ml orally 
    • antacid plus alginate prepartions 10 to 20 ml orally 
    • A histamine h2 receptor antagonist e.g. ranitidine 150 mg once or twice daily 
    • PPI 
    • Fail to respond to PPI after 8 weeks warrants further investigation
    • If moderate to severe symptoms (twice or more per week) --> start on PPI
  • Maintenance therapy
    • try stopping PPI (30% of people have prolonged remission of symptoms)
    • step down to the lowest dose possible 
    • NPS has an educational module on how to stop PPIs. 
    • PPIs are fairly safe to use but the safety profile in long term use is uncertain. Some potential side effects associated with long term use include: fracture, increase enterc infection, vitamin b12 deficieny, iron and magnesium deficiency and pneumonia. (Please see reference 3) 
References:
  • John Murtagh's general practice 5th edition 
  • eTG 
  • http://www.nps.org.au/publications/health-professional/medicinewise-news/2015/proton-pump-inhibitors


Approach to dyspepsia

Dyspepsia


** Consider heartburn as ischaemic heart disease until proved otherwise **

Murtagh's diagnostic model

Probability diagnosis

Serious disorders not to be missed

  • Neoplasia: stomach, pancreas, oesophagus
  • Cardiovascular: ischaemic heart disease and congestive cardiac failure
  • Pancreatitis
  • Peptic ulcer 

Pitfalls 

  • Myocardial ischaemia
  • Food allergy (e.g. lactose intolerance)
  • Pregnancy (early)
  • Biliary motility disorder
  • Other gall bladder disease
  • Post vagotomy
  • Duodenitis
  • Rarities
    • Hyperparathyroidism
    • Mesenteric ischaemia
    • Zollinger - Ellison syndrome
    • Kidney failure
    • Scleroderma




Saturday, 23 January 2016

Approach to dizziness

Dizziness is a common exam topic and a common GP presentation. We often have a laugh at the emergency department when an elderly Greek woman presents with dizziness. It is probably that we know that we will never make the dizziness go away. Many causes of dizziness are benign, however, some of them are serious and can be potentially fatal if missed.

Dizziness means different thing to different people. It is important to clarify what they actually mean by dizziness.

As per usual, John Murtagh attempts to simplify the diagnostic process:

Murtagh's diagnostic model 

Probability diagnosis 

  1. - Anxiety-hyperventilation 
  2. - Postural hypotension 
  3. - Simple faint - vasovagal
  4. - Acute vestibulopathy
  5. - Benign Paroxysmal Positional Vertigo
  6. - Motion sickness
  7. - Post head injury
  8. - Cervical dysfucntion/spondylosis 

Serious disorders not to be missed

1. Neoplasia
2. Intracerebral infection (e.g. abscess)
3. Cardiovascular 
  • Arrhythmias
  • Myocardial infarction 
  • Aortic stenosis 
4. Cerebrovascular 
5. Multiple sclerosis 

pitfalls (often missed)

  1. Ear wax - otosclerosis
  2. Arrhythmias
  3. Hyperventilation 
  4. ETOH and other drugs
  5. Cough or micturition syncope
  6. Vertiginous migraine/migrainous vertigo
  7. Parkinson's disease 
  8. Meniere syndrome (overdiagnosed) 
  9. Ramsay-Hunt syndrome 
  10. Rarities
    • Addison disease
    • Neurosyphilis
    • Autonomic neuropath
    • Hypertension 
    • Subclavian steal 
    • Perilymphtic fistula
    • Shy-Drager syndrome 

Seven Masquerades checklists

1. Depression 
2. Diabetes
3. Drugs
4. Anaemia 
5. Thyroid disorder
6. Spinal dysfunction 
7. UTI 

Other resources about dizziness

  • http://blogs.brown.edu/emergency-medicine-residency/you-make-me-dizzy-miss-lizzy-hints-for-assessing-acute-dizziness/



Vertebrobasilar insufficiency

Condition

  • Vertbrobasilar insufficiency 
Definitions
Main features 
  • Sudden onset 
  • Usually over the age of 50 
  • Has cardiovascular risk factors  
  • Symptoms depend on the area of the brain that is affected, but patients can experience: 
    • Vertigo 
    • Visual field defects (diplopia, hemianopia)
    • Auditory phenomena (sudden sensorineural hearing loss) 
    • Facial numbness or parenthesis
    • Dysphagia, dysarthria, hoarseness
    • Syncope (drop attacks)
    • Hemisensory extremity symptoms 
  • Isolated vertigo symptom is unusual. It usually accompanies other neurological symptoms
Investigations
  • Clinic test: **Random glucose**, ECG
  • As per any other TIAs  (Fasting lipid, fasting glucose, FBE, UEC, Holter, U/S Carotid)
  • MRA for a good image of the posterior fossa or if not available, CTA
Management 
  • Refer for hospital admission if happens acutely for better outcome
  • Otherwise 
    • organise urgent CTB to exclude other pathology 
    • if no intracranial haemorrhage, start aspirin
    • start anti hypertensive and statin 
    • organise ECG, blood test, holter monitor and carotid ultrasound. (ideally within 24 hrs)
    • refer to neurologist for a second opinion 
References:
  • John Murtagh's general practice 5th edition 
  • Wikipedia 

Hyperventilation

Condition

  • Hyperventilation 
Main features
  • Usually related to anxiety and depression 
  • Main symptoms 
    • breathlessness
    • palpitations
    • sweating
    • dry mouth with aerophagy 
    • agitation 
    • fatigue and malaise 
  • Other symptoms 
    • paraesthesia of the extremities
    • perioral paraesthesia
    • carpopedal spasm 
Management 
  • As per treatment of anxiety or depression 
  • reassuring Susan that there is no serious physical underlying cause, but ensure careful follow up 
  • Advising susan to consciously slow down her respiratory rate and encouraging her to identify the cause, and the control the rate and depth of her breathing 
  • breath into a paper bag
Reference
  • RACGP Check program dizziness 2011

Menière syndrome

Condition

  • Menière syndrome 
Definition 
  • Hydrous of the labyrinth such as intralabyrinthine pressure effect. The most likely cause is an episode of viral labyrinthitis that leaves the labyrinth damaged and liable to bouts of endolymphatic hydrops. 
  • Secondary forms related to otosclerosis, trauma and longstanding sensorineural hearing loss are also implicated and recognised. 
History 
  • Characterised by paroxysmal attacks of 
    • vertigo
    • tinnitus 
    • hearing loss (fluctuating or progressive) 
  • Also possibly characterised by:
    • nausea and vomiting 
    • sweating and pallor
  • Abrupt onset - patient may fall 
  • Attacks last at least 20 minutes
  • Variable interval between attacks (twice per month to twice per year)
  • Examination 
    • nystagmus (during at attack, often to side opposite the affected inner ear)
    • sensorineural deafness
    • caloric test impaired vestibular function 
  • Audiometry 
    • sensorineural deafness
    • loudness recruitment
    • electrocochleography 
    • characteristic change
Examination 
  • Sensorineural deafness
  • Horizontal nystagmus 
  • Caloric test demonstrates impaired vestibular function
  • Electrocochleography: abnormal in Meniere syndrome 
  • Normal in between attacks 
Treatment
  • Acute management 
    • Prochlorperazine 12.5 mg
  • Long term management 
    • advice to avoid caffeine
    • Avoid excessive intake of ETOH and tobacco
    • Advice for a low salt diet - this is the mainstay of treatment
    • Alleviating anxiety by using appropriate sedation and, preferable counselling such as cognitive behaviour therapy
    • Referral for a neurological assessment 
    • Prescribing a diuretic to be taken daily. eTG recommends hydrochlorothiazide 25mg orally daily 
    • Betahistine is recommended as a vasodilator and it may increase the blood supply to the inner ear, 8 mg to 16 mg orally, 2-3 times daily 
    • Introduce to Meniere support group 
  • Management if symptoms persist despite treatment
    • myringotomy with grommet
    • endolymphatic sac decompression 
    • labyrinthectomy 
Reference:
1. John Murtagh's General Practice 5th edition
 2. Therapeutic guideline 

Acute peripheral vestibulopathy

Condition

  • Acute peripheral vestibulopathy 
Definition 
  • Acute vestibular failure is the sudden loss of function in one balance organ 
  • The presumptive cause of acute peripheral vestibulopathy is vestibular neuritis (also known as vestibular neuronitis). Recent evidence suggests reactivation of herpes simplex type 1 virus in the vestibular ganglion is responsible 
History 
  • Mainly in young adults and middle aged people
  • Single attack of vertigo 
  • Abrupt onset of persistent vertigo
  • Often follows a flu-like illness
  • Accompanied by nausea and vomiting
  • No hearing loss or tinnitus
  • Gradual recovery over days to weeks
  • Spontaneous horizontal nystagmus 
  • Caloric stimulation confirms impaired vestibular function 
Examination 
  • Spontaneous horizontal nystagmus 
  • Check ear to exclude suppuration in the middle ear or mastoid cavity 
  • Head impulse test (positive test points towards acute vestibular syndrome, click on it to watch a video on youtube) 
  • Hallpike maneuvre
  • Rhomberg test
    • Positive Romberg indicates loss of proprioceptive or vestibular input, support the diagnosis of Romberg test
  • Bedside assessment of hearing
  • Assessment of gait and preponderance to veer to one or other side
Diagnostic triad
  • acute vertigo + nausea + vomiting = vestibular neuritis
  • same symptoms + hearing loss +/- tinnitus = acute labyrinthitis
Differential diagnoses

  • stroke
  • Meniere disease
  • BPPV
  • Vestibula migraine
Red flags
  • acute unaccustomed headache
  • inability to stand or walk
  • the presence of spontaneous direction changing nystagmus
  • spontaneous vertical nystagmus
  • a normal head impulse
  • the presence of additional focal neurological signs

Treatment
  • Short term
    • Education: spontaneous resolution usually after 1 week
    • Prochlorperazine 12.5 mg 
    • Short course of corticosteroids such as prednisolone often helps
  • Medium
    • vestibular physiotherapy could be considered
Reference:
John Murtagh 5th edition p. 497
Check program ENT Case 4 2011

Benign paroxysmal positional vertigo

Condition

  • Benign paroxysmal positional vertigo (BPPV)
Definition 
  • Common type of acute vertigo that is induced by changing head position - particularly tilting the head backwards, changing from a recumbent to a sitting position or turning to the affected side
  • The underlying cause is unknown. Generally accepted theory of causation is that fine pieces of calcium carbonate present in the utricle and become loose, settle at the bottom of one o f the semicircular canal, and generate endolymphatic movement, causing nystagmus with certain head positions. 
History
  • Occurs in clusters that persist for several days 
  • Usually a latency period of several seconds following a head movement before symptoms develop, and symptoms subside within 10-60 seconds, usually fewer than 30 seconds. 
  • Female to male ration is 2:1
  • Attacks are not accompanied by vomiting, tinnitus or deafness (nausea may occur)
  • Recurs periodically for several days 
Examination
  • Normal hearing and vestibular function 
  • Positive hallpike manoeuvre
    • Brief latency - usually a brief latency of several seconds before the onset of nystagmus and it usually lasts 10-20 seconds
    • Nystagmus - usually torsional but may be horizontal. 
    • Reversal- upon sitting after a positive manoeuvre, the direction of nystagmus is reversed for a brief period of time
    • Fatigability - repetition of the test will result in less nystagmus each time 
  • Normal cranial nerve examination 
Murtagh's diagnostic triad


Treatment
  • Re-assurance that this condition usually resolves spontaneously  
  • Explanation of avoidance measures 
  • Brandt-Daroff exercises (Table 1 from RACGP check program dizziness
  • Epley manoeuvre 
    • The patient sits on the bed with head slightly extended and turned 45 degrees in the direction that precipitated the vertigo 
    • The patient then lies on their back with the head hanging over a pillow placed at the shoulder level 
    • From this position, turn the head through 90 degrees to the opposite side and wait 1 minute
    • Slowly sit the patient upright with the head in a neutral position and sit still for 10 minutes 
Reference:
  • John Murtagh 5th ediation 497
  • Check program RACGP 2011 Dizziness

Posterior Fossa Tumour

Posterior fossa tumour has a very different differential in an adult as opposed to a child

Adult

  • Cerebella meastases (most common) 
    • especially lung cancer and breast cancer
    • also melanoma, thyroid malignancies and renal cell cancer
  • Haemangioblastoma: most common primary brain tumour
  • astrocytomas and medulloblastomas are rare in the posterior fossa of adults (< 1% all tumours) 
Child 
  • posterior fossa astrocytoma
    • pilocytic astrocytoma : most common 
    • brainstem glioma 
  • Medulloblastoma 
  • Ependymoma
  • Atypical teratoid/rhabdoit tumour
  • Haemangioblastoma 
  • Teratoma 
** Overall 50-55% of all brain tumours in children are found in the posterior fossa**

Reference:
  • http://radiopaedia.org/articles/posterior-fossa-tumours

Acoustic Neuroma

Condition

  • Acoustic neuroma 
Definition
  • Acoustic neuromas are intracranial, extra-axial tumours that arise from the Schwann cell sheath investing either the vestibular or cochlear nerve.
History 
  • Unilateral hearing loss
  • Tinnitus 
  • Headache 
  • Balance disturbance 
  • Facial weakness
  • Facial numbness 
  • Lower CN palsy 
The most common presentation is overwhelmingly unilateral hearing loss. Assume anyone presents with sensorineural hearing loss with acoustic neuroma until proven otherwise. The following is a chart from e-medicine, here is the link to the full article


Examination
  • occipital pain on the side of the tumour
  • VIII nerve damage
    • unilateral sensorineural deafness developing gradually over a period of months or years 
    • around 5% will have sudden hearing loss
    • vertigo which may be quite mild and tinnitus are common 
    • caloric paresis may be demonstrable 
  • V nerve damage
    • depression of corneal reflex occurs early. Facial pain, paraesthesia and numbness develop
  • VII nerve damage
    • facial weakness is unusual 
  • IX, X, XI nerve damage
    • rare, presents dysphagia, change in voice, palatal weakness
  • Compression effects of large tumours
    • on cerebellum - ataxia, loss of coordination on ipsilateral side, nystagmus
    • on pons - contralateral hemiparesis
    • on aqueduct and 4th ventrcle - raised intracranial pressure e.g. headache 

Investigations
  • Audiometry: selective sensorineural hearing loss in the right ear and delayed acoustic reflex (movement of the tympanic membrane in response to intense sound).
  • Auditory branstem response: brainwave activity in response to sound, and tests the pathway from the cochlea to the brainstem. This should show an absence of waveforms and an increase in the latency of the fifth wave
  • MRI

Murtagh's diagnostic triad
  • unilateral tinnitus + hearing loss + unsteady gait = acoustic neuroma 

Treatment
  • Referral to Neurosurgeon for excision 
References:
  • John Murtagh 5th edition 
  • Emedicine 
  • gpnotebook.co.uk 



Tuesday, 5 January 2016

Community acquired Pneumonia

Condition: Pneumonia


What bacteria commonly cause pneumonia in Australia?
- Most common cause is streptococcus pneumonia
- atypical pathogens mycoplasma pneumoniae, chlamydophila pneumoniae and legionella species
- Haemophilus influenzae < 5 % CAP, predominately in people with COPD
- In tropical regions of Australia, gram negative organisms Burkholderia pseudomallei and Acinetobacter baumanni

How do patients present?
- fever
- rigors
- malaise
- anorexia
- dysnoea
- cough
- purulent sputum
- haemoptysis
- pleuritic chest pain

What are the examination findings?
- fever, cyanosis, confusions, tachypnoea, tachycardia, hypotension, signs of consolidation (diminished expansion, dull percussion note, increase tactile vocal fremitus/vocal resonance, bronchial breathing) and a pleural rub.

How do you treat pneumonia ?

Risk stratification. Assess severity and cater treatment according to severity.


If the following features are present, it is likely that the patient suffers from severe pneumonia and will require in-patient management.

Red flags for community acquired pneumonia in adults
- RR> 30
- Systolic bp < 90
- SaO2 < 92 %
- Acute onset confusion
- HR > 100 bpm
- Multilobar involvement on chest x-ray

CAP treatment flowchart from therapeutic guideline

Mild pneumonia: amoxycillin 1g orally 8 hourly 5 to 7 days or doxycycline 100 mg orally 12 hourly for 5-7 days. (Use this regime if patient can return for review in 48 hrs, if not, give both)

If hypersensitve to amoxycillin, use doxycycline. If can't tolerate doxycycline, use clarithromycin

Other options if hypersensitiv to penicillin, cefuroxime 500 mg 12 hourly (given it is not immediate hypersensitive), consider switching to moxifloxacin 400 mg orally for patients with immediate hypersensitivity to penicillins

Moderate pneumonia: Try to obtain culture before starting treatment.

Benzylpenicillin 1.2 g IV 6 hourly until significant improvement then amoxycillin 1g orally 8 holy for a total of 7 days + doxycycline 100 mg orally 12 hourly for 7 days. (If doxycycline is in appropriate e.g. in pregnant women, switch to clarithromycin)

If hypersensitive to penicillin, use ceftriaxone 1 g IV daily until significant improvement, then cefuroxime 500 mg orally, 12 hourly for a total of 7 days

References:
- Therapeutic guideline